医療従事者の為の最新医療ニュースや様々な情報・ツールを提供する医療総合サイト

BGI Releases 1st Panoramic Atlases of Life

2022年06月02日 PM05:00
このエントリーをはてなブックマークに追加


 

SHENZHEN, China

International scientists led by China’s BGI•Research released the world’s first panoramic spatial atlases of life on May 4, examining the cellular dynamics of organisms at different developmental stages and providing potentially significant new information for disease treatment, development and aging, and an improved understanding of biological evolution.

In a series of studies published in Cell Press journals, members of the Spatio-Temporal Omics Consortium (STOC), an international scientific consortium, used the BGI-developed spatially resolved transcriptomics technology Stereo-seq to produce spatio-temporal cellular maps of mice, Drosophila, zebrafish and the Arabidopsis (thale cress) plant.

The papers demonstrate how Stereo-seq has achieved a major breakthrough in spatial resolution and panoramic field of view, enabling analysis of the distribution and placement of molecules and cells in situ, and over time.

Over 80 scientists from leading universities in 16 countries have so far collaborated as part of STOC focusing on using spatially resolved, cellular resolution omics technologies to map and understand life.

Spatial transcriptomics technology resolves previous issues identifying characteristics of single cells within a biological tissue. It builds on the achievements of single-cell sequencing, elevating it to the next level by enabling scientists to track a cell’s precise location and how it interacts with neighbouring cells.

Scientists used Stereo-seq to examine the early embryonic development of mice, particularly from 9.5 to 16.5 days, during which embryonic development is occurring at a fast rate. Stereo-seq generated the Mouse Organogenesis Spatiotemporal Transcriptomic Atlas (MOSTA), which maps with single-cell resolution and high sensitivity, the kinetics and directionality of transcriptional variation during mouse organogenesis.

“Stereo-seq is a transformational breakthrough in spatial transcriptomics technology and is the most powerful technology in this field of life sciences today,” said Dr. Liu Longqi of BGI•Research, one of the papers’ corresponding authors. “We now have the technology to map a panoramic atlas of every cell in an organism, according to their individual biomolecular profiles, in space and over time.”

“The successful application of our Stereo-seq technology for development has significant implications for the future of genomic research on human diseases,” said co-corresponding author Dr. Xu Xun, director of BGI•Research. “Demonstrating that this technology can pinpoint certain cells that indicate future disease will be critical for diagnostics and therapeutics for a number of conditions.”

View source version on businesswire.com: https://www.businesswire.com/news/home/20220530005196/en/

CONTACT

Xiaolin Chen

E-mail: media@genomics.cn

同じカテゴリーの記事 

  • EMS Kegel Trainer BODYDOCTOR Opens New Era of Health Care Solutions in Global Femcare Market
  • EMSケーゲルトレーナー BODYDOCTOR、Femcareのグローバル市場でK-HEALTH CAREに注目が集まる
  • InnoCare Announces Dosing of First Patient in Clinical Study of the Combination of SHP2 Inhibitor ICP-189 and EGFR Inhibitor Furmonertinib
  • METIS第3相臨床試験で主要評価項目を達成、非小細胞肺がんからの脳転移患者における頭蓋内進行までの期間を統計学的に有意に延長
  • Poxel to Report Its 2023 Annual Results by the End of April 2024