医療従事者の為の最新医療ニュースや様々な情報・ツールを提供する医療総合サイト

EdiGene Announces Publication by Company Scientific Founder in Nature Biotechnology of LEAPER™ 2.0, an Updated Version of the RNA Base Editing Technology Using Engineered Circular ADAR-recruiting RNAs

2022年02月11日 AM01:51
このエントリーをはてなブックマークに追加


 

BEIJING & CAMBRIDGE, Mass.

EdiGene, Inc., a global biotechnology company, today announced its Scientific Founder Wensheng Wei’s lab at Peking University has published a research article in Nature Biotechnology on an upgraded version of LEAPER™ (Leveraging endogenous ADAR for programmable editing of RNA) that shows significantly improved efficiency and fidelity of RNA editing in vitro and in vivo.

LEAPER™ was developed at the lab at Peking University led by Professor Wensheng Wei and was first reported in Nature Biotechnology in 2019.

“LEAPER 2.0 incorporates multiple engineered elements and significantly improves the on-target editing efficiency while reducing the bystander off-target editing events in vitro and in vivo,” Professor Wei said. “LEAPER is a powerful and versatile RNA editing technology, and our relentless research effort continues to improve its precision and efficiency to support broader applicability for therapy and basic research.”

The paper, Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo in Nature Biotechnology, is available at https://www.nature.com/articles/s41587-021-01180-3.

“LEAPER™ has distinct advantages over other gene-editing technologies. With LEAPER™ 2.0, we have achieved proof of concept in multiple preclinical models through AAV delivery, and we are excited about its therapeutic potential as in vivo RNA editing therapies,” said Dong Wei, Ph.D., CEO of EdiGene. “We have built up internal capabilities both in Beijing and in Boston and formed collaborations with top research institutes to advance our lead programs, and are in discussions with potential industry partners as well to accelerate the translation of this exciting platform for patients in need worldwide.”

In November 2021, EdiGene announced separate research collaborations with the University of Wisconsin-Madison and Peking Union Medical College Hospital designed to further advance the development and translation of LEAPER™.

Both Prof. Wensheng Wei and Dr. Dong Wei will be presenting the research and therapeutic application of LEAPER™ 2.0 at the 3rd RNA Editing Summit on April 5-7, 2022 in Boston, and Dr. Dong Wei will be presenting at the 23rd annual TIDES USA Conference on May 9-12, 2022 in Boston.

About EdiGene, Inc
EdiGene is a global, clinical-stage biotechnology company focused on translating gene editing technologies into transformative therapies for patients with serious genetic diseases and cancer. The company has established its proprietary ex vivo genome-editing platforms for hematopoietic stem cells and T cells, in vivo therapeutic platform based on RNA base editing, and high-throughput genome-editing screening to discover novel targeted therapies. Founded in 2015, EdiGene is headquartered in Beijing, with offices in Guangzhou and Shanghai, China and Cambridge, Massachusetts, USA. More information can be found at www.EdiGene.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20220210005778/en/

CONTACT

Xiaomeng Zhang

EdiGene, Inc.

+86 10-80733899

media@edigene.com

Related Posts Plugin for WordPress, Blogger...

同じカテゴリーの記事 

  • Genuv Announces Preclinical Data to be Released at Two Medical Conferences in June
  • IntelliCentrics Seeks Strategic Alliance With Taiwanese Health Insurance Providers to Serve Millions of Taiwanese Patients Ensuring They Have Remote Access to Trusted, High Quality Healthcare.
  • 中智全球寻求与台湾医疗保险公司结成战略联盟,为数百万台湾患者提供服务,确保他们能够远程获得可靠及优质的医疗保健服务。
  • Sermo调查显示,今年ASCO的与会肿瘤学家对新的肺癌和乳腺癌研究最感兴趣
  • 訂正・差し替え SCAI 2022 Scientific Meeting で心原性ショックの予後改善に向けた Impella の研究と進歩を大きく紹介