医療従事者の為の最新医療ニュースや様々な情報・ツールを提供する医療総合サイト

PeptiDream Announces New Peptide Drug Conjugate (PDC) Discovery Deal with Shionogi

2019年01月23日 PM05:31
このエントリーをはてなブックマークに追加


 

KAWASAKI, Japan

PeptiDream Inc., a public Kanagawa-based biopharmaceutical company (“PeptiDream”)(TOKYO:4587) announced today that it has entered into a multi-program collaborative research agreement with Osaka-based Shionogi & Co., Ltd (“Shionogi”)(TOKYO:4507) for the discovery and development of a series of blood brain barrier (BBB) penetrating peptide drug-conjugates (PDCs).

PeptiDream will use its proprietary Peptide Discovery Platform System (PDPS) technology to identify macrocyclic/constrained peptides against multiple targets known to be involved in shuttling compounds across the BBB, selected by Shionogi. Identified peptides will then be optimized to maximize BBB penetration, cargo conjugation, and the types of cargoes they are capable of shuttling across the BBB. The companies will then work together to produce novel PDC therapeutics for CNS indications, by combining BBB carrier peptides, identified by PeptiDream, with Shionogi’s own drugs and/or drug candidate compounds.

Under the terms of the agreement, PeptiDream will receive an undisclosed upfront payment, annual R&D funding, and is eligible for payments associated with the achievement of certain preclinical and clinical development milestones, in addition to royalties on sales of any products containing the PDCs commercialized by Shionogi.

PeptiDream will continue to work with Shionogi to develop macrocyclic/constrained peptides against multiple targets of interest selected by Shionogi, and to optimize hit peptides into therapeutic peptides or small molecule products using PeptiDream’s PDPS technology, under the original agreement in February 2016.

[Comment from Dr. Keiichi Masuya, Executive Vice President of PeptiDream Inc.]
There exists considerable unmet medical needs in treating CNS disorders largely due to the challenges in getting drugs across the BBB. Peptides capable of carrying a conjugated cargo across the BBB represents an exciting new avenue for treating CNS disorders. We are extremely excited to be working with our strong collaboration partner Shionogi in these efforts, conjugating our BBB penetrating peptide candidates with Shionogi’s CNS drug candidates. We believe there are potentially many applications for these BBB carrier peptides, and believe that we can improve and accelerate novel treatments for CNS disorders.

In the past eight years, PeptiDream has established funded discovery collaborations with 19 of the leading pharmaceutical companies; Amgen, AstraZeneca, Bristol-Myers-Squibb, Lilly, GlaxoSmithKline, Novartis, Mitsubishi Tanabe, Daiichi Sankyo, Merck & Co., Inc., Kenilworth, NJ, USA, Sanofi, Teijin, Kyorin, Ipsen, Genentech, Shionogi, Asahi Kasei, Janssen, Bayer, and Santen, all of which are active and ongoing. In addition, PeptiDream has transferred its PDPS discovery platform for broad use to Bristol-Myers-Squibb, Novartis, Lilly, Genentech, Shionogi, and Merck (Merck & Co. Inc., Kenilworth NJ, USA).

View source version on businesswire.com: https://www.businesswire.com/news/home/20190123005292/en/

CONTACT

Enquiries:
PeptiDream Inc.
Patrick C Reid,
+81-44-270-1270 (Kanagawa)
EMAIL: p-reid@peptidream.com
https://www.peptidream.com/

Related Posts Plugin for WordPress, Blogger...

同じカテゴリーの記事 

  • Seoul Viosys’ Violeds Modules Proven to Disinfect 99% of Airborne Viruses in a Recent Testing Result
  • Kaye推出适用于冷链运输市场的Kaye® Log -80℃ 疫苗温度记录器,以满足COVID-19疫苗储存和运输的要求
  • Kaye® (ケイ)は、COVID-19ワクチンの輸送・保管のニーズに応えるためにKaye® ログ -80ワクチン温度ロガーを、コールドチェーン市場向けに導入(発売)します。
  • Aurinia Announces Collaboration and Licensing Agreement with Otsuka Pharmaceutical Co., Ltd. for the Development and Commercialization of Voclosporin in Europe and Japan
  • DNP的新型非接触式透明屏幕可通过手的动作进行操作