医療従事者の為の最新医療ニュースや様々な情報・ツールを提供する医療総合サイト

SanBio: Acquisition of a Patent Portfolio Regarding Cell Medicines Derived from Mesenchymal Stem Cells

2018年09月03日 AM11:30
このエントリーをはてなブックマークに追加


 

TOKYO

The SanBio Group, a scientific leader in regenerative medicine for neurological disorders, today announced the acquisition of a patent portfolio regarding cell medicines derived from mesenchymal stem cells (hereinafter the Patent Portfolio).

This press release features multimedia. View the full release here: https://www.businesswire.com/news/home/20180902005047/en/

Image of the Technology of MSC1 and MSC2 (Graphic: Business Wire)

Image of the Technology of MSC1 and MSC2 (Graphic: Business Wire)

The Patent Portfolio is pertaining to technology (hereinafter the Technology) discovered by Dr. Aline Betancourt, a researcher at Tulane University, that enhances anti-inflammatory and pro-inflammatory functions of mesenchymal stem cells (MSCs)*1 by stimulating specific Toll-like receptors (TLRs)*2 expressed on mesenchymal stem cell membranes while maintaining safety and tolerability profile of mesenchymal stem cells. Mesenchymal stem cells induced to have enhanced anti-inflammatory function (MSC2 phenotype) and those induced to have reinforced pro-inflammatory function (MSC1 phenotype) using the Technology are more likely to migrate to injury sites and express higher homogeneity compared with naïve, uninduced mesenchymal stem cells, indicating their therapeutic potential as highly safe and effective agents.

The MSC2 phenotype, with its enhanced anti-inflammatory function, has therapeutic potential against demyelinating disorders (e.g., optic neuritis, multiple sclerosis, and Krabbe disease), diabetic neuropathy, and inflammatory disorders (e.g., rheumatoid arthritis and Crohn’s disease). Pre-clinical studies using animal models of each disease are currently underway. Regarding the MSC1 phenotype, which demonstrates reinforced pro-inflammatory function, pre-clinical studies have shown that it attenuates tumor growth as opposed to uninduced mesenchymal stem cells that promote proliferation of tumor cells. Based on such findings, development of MSC1 phenotype for the treatment of cancer is highly anticipated.

SanBio is currently conducting phase 2 clinical trials of regenerative cell medicine SB623 in its propriety development pipeline targeting chronic motor deficit from ischemic stroke in the US and targeting chronic motor deficit from traumatic brain injury (TBI) in Japan. SB623 consists of mesenchymal stem cells derived from adult bone marrow that undergo a genetic modification. It is a stem cell-based therapy with potential to promote brain tissue regeneration that helps patients with ischemic stroke or TBI recover lost functions when administered to the area around the injury site. In animal studies where SB623 was administered to brains of mouse models of ischemic stroke, phenomena such as migration of neural stem cells to injury sites, proliferation of nerve cells, and angiogenesis were observed.

Acquisition of the Patent Portfolio will enable SanBio to expand its development pipeline into areas of inflammatory disorders and cancer in addition to neurological disorders targeted by SB623. By leveraging its knowledge and expertise relating to mesenchymal stem cells SanBio has cultivated so far, SanBio will work to develop new cell medicines based on the Patent Portfolio.

 
*1:   Mesenchymal stem cells are multipotent cells that possess self-renewal capacity. They can differentiate into osteoblasts, cardiomyocytes, chondrocytes, tenocytes, adipocytes, and other cells that are part of the mesenchymal system.
*2: Toll-like receptors recognize both exogenous (e.g., microbial and viral components) and endogenous (e.g., proteins released in response to tissue injury) danger signals. They are usually expressed on the membranes of sentinel cells such as macrophages and dendritic cells. Ten types of Toll-like receptors that recognize structurally different molecules have been identified in humans so far.
 

View source version on businesswire.com: https://www.businesswire.com/news/home/20180902005047/en/

CONTACT

For more information, contact:
SanBio Co., Ltd.
Masahito
Kumagae, +81-3-6264-3481
Management Administration

Related Posts Plugin for WordPress, Blogger...
 

同じカテゴリーの記事 

  • Seattle Genetics Announces ADCETRIS® (Brentuximab Vedotin) Approval in Japan for Frontline Hodgkin Lymphoma
  • MicuRx Announces Receipt of FDA’s QIDP and Fast Track Designations for Contezolid and Contezolid Acefosamil
  • SanBio: Notice Regarding an Equity and Business Alliance Between Five Companies for Joint Research on the Appropriate Use, Adoption, and Stable Distribution of Regenerative Cell Medicine SB623
  • SanBio: Supplementary Information to the Notice Regarding an Equity and Business Alliance Between Five Companies for Joint Research on the Appropriate Use, Adoption, and Stable Distribution of Regenerative Cell Medicine SB623
  • 首例神经母细胞瘤患者成功接受采用自然杀伤T细胞(CAR-NKT)的创新型CAR疗法